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 NANOSOMES |
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| Molecular
Therapeutics, Inc is developing a number of novel imaging
and therapeutic agents based
on the proprietary nanoparticle technology licensed from
University of Michigan.We designed and built a multifunctional
Dynamic Nano-Platform called “Nanosomes” that
non-invasively integrates the development of novel imaging
and therapeutic agents for cancer and cardiovascular
disease indications. Nanosomes are 50-60 nm bio-compatible
nanoparticles incorporating variable components for detection
and treatment. The Nanosome platform provides the core
technology with interchangeable components that provide
ultimate flexibility in targeting, imaging and treatment
of cancer and cardiovascular disease indications. |
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| THERAPEUTICS |
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To
determine the feasibility of exploiting nanosome technology
for the development of therapeutics, we have incorporated
photofrin, a photodynamic therapy (PDT) agent, into nanosomes.
The PDT method employed here differs from traditional
approaches in that no drug is delivered to the cancer
cell, but only the cytotoxic singlet oxygen from the
nanosomes. Our preliminary data suggests that we can
selectively deliver photofrin-containing nanosomes to
brain tumors and cause tumor cell-kill upon exposure
to light (630 nm wavelength), suggesting the feasibility
of this technology to develop tumor-specific therapeutic
agents. |
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| MOLECULAR
TARGETING |
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| Nanosomes also incorporate molecular
targeting elements such as receptors, peptides and
antibodies specific
to the tumor cells or vasculature. Targeted nanosomes
have the potential to improve efficacy by increasing
the amount of therapeutic agent delivered to the
site, and to minimize toxicity by reducing systemic
exposure. |
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| IMAGING |
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We have chosen Magnetic Resonance Imaging
(MRI) as a primary method for the detection and monitoring
of diseases. For enhanced detection sensitivity, we
are developing iron-oxide and gadolinium-containing
chelates.
Modulation of the plasma half-life of nanosomes
is also necessary for efficient MRI detection and
monitoring. This can be achieved by means of a hydrophilic
coating (e.g. polyethylene glycol - PEG) on the surface of the nanosomes,
providing
reduced uptake by the reticuloendothelial system (RES), and resulting in
both increased delivery of the particles to the tumor
sites and reduced toxicity to
other body tissues. |
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